APOE and Alzheimer disease: Finally, and perhaps most relevant are the recent findings that carriers of both the ApoE4 (cholesterol transporter) allele and H63D-HFE variant (iron accumulation, cholesterol decrease) had increased risk for and 5.5 year earlier onset of AD (Moalem et al., 2000; Sampietro et al., 2001; Combarros et al., 2003; Percy et al., 2008).