For example, the observation that cells carrying the H63D-HFE allele have lower baseline levels of total cholesterol and exhibit slower growth relative to those expressing WT-HFE (Ali-Rahmani et al., 2014a) supports the idea that H63D-HFE positive patients with AD will differ from those with WT-HFE in their response to statin therapy. Here, HFE is linked to Alzheimer disease.