Cationic and anionic liposome polycation-DNA nanoparticles loaded with C-Myc siRNA and Doxorubicin suppressed MDR1 gene expression via silencing the transcription level by targeting transcription factors, intercalation of Doxorubicin, topoisomerase II inhibition, transcription inhibition of resistant tumors and tumor regression (Chen et al., 2010). The gene discussed is ABCB1; the disease is neoplasm.