Doxorubicin/Mitomycin/5-Fluorouracil loaded hydroxyapatite nanoparticles acted synergistically with recombinant mutant human tumor necrosis factor-α (rmhTNFα) reduced P-gp levels of mRNA, increased intracellular concentration in human hepatoma xenografts of HepG2/ADM cells and suppressed tumor cell growth by apoptosis (Al-Bataineh et al., 2010; Ronaldson et al., 2010). This evidence concerns the gene PGP and neoplasm.