TF and cancer: Transferrin modified ceramide liposomes initiated lysosomal membrane permeabilization resulting in leakage of hydrolytic enzymes (cathepsins) into cytoplasm, induced cancer cells apoptosis and revealed antitumor and pro-apoptotic effects in A2780-ovarian carcinoma xenograft mouse model compared to ceramide-free and ceramide-loaded non-modified liposomes (Koshkaryev et al., 2012).