BCL2 and neoplasm: Wu Yanan et al. studies reversed the effect of 5-Bromotetrandrine and magnetic iron oxide nanoparticle combining Daunorubicin in xenograft leukemia model and inhibited expression of Bcl-2 protein and up-regulated BAX and CASPASE-3 protein expression in K562/A02 cells xenograft tumor (Yanan et al., 2009).