Cationic cholesterol derivative with hydroxyethylamino head group, cholesteryl-3bcarboxyamidoethylene-N-hydroxyethylamine (I) on liposome significantly promoted gene transfection, Bcl-2 antisense phosphorothioate oligonucleotides complexed with cationic liposomes suppressed human cancer cell growth and induced apoptosis in human cervix epithelial carcinoma cell lines HeLa and mouse fibroblast NIH3T3 cells (Okayama et al., 1997). The gene discussed is BCL2; the disease is cancer.