PGP and breast cancer: Lipid/particle assemblies (LNPs) loaded with Doxorubicin in DMAB-modified PLGA nanoparticles coated with DPPC lipid shell significantly increased accumulation and improved nucleus targeting in MCF-7 cells and P-gp over expressing resistant MCF-7/ADR cells relative to free drug and reversed the transporter-mediated drug resistance in human breast cancer.