BCL2 and neoplasm: Matrine (active component of Sophora flavescence dry roots) in human gastric cancer MKN45 tumor cells activates caspase-3, 7 and up-regulates pro-apoptotic molecules Bok, Bak, Bax, Puma, Bim and induces apoptosis via Bcl-2 (Noguchi et al., 2003; Luo et al., 2007).