Lonidamine and Paclitaxel dual loaded PLGA/PEG/EGFR-peptide targeted nanoparticles at 1 μM paclitaxel/10 μM lonidamine dose revealed <10% cell viability for all hypoxic cell lines and <5% cell viability for all normoxic cell lines overexpressing EGFR in human breast and ovarian cancer cell lines. Here, EGFR is linked to ovarian cancer.