MDR1-siRNA encapsulated magnetic chitosan iron oxide nanoparticle reversed MDR effect on MDR1 gene in BT325 glioblastoma cell line with 70–80% transfection efficiency by reduced expression of MDR1 at mRNA and protein level and decreased IC50 values in normal BT325 and transfected cell (Zhao et al., 2013). This evidence concerns the gene ABCB1 and glioblastoma.