APOE and Stroke: While the ApoE3 isoform is not associated with an increased risk of CVD, the ApoE4 isoform is a major risk factor for CVD, such as coronary heart disease, arrhythmias, and stroke (Lahoz et al., 2001; Eichner et al., 2002; Song et al., 2004; Mahley et al., 2009).