APOE and Alzheimer disease: ApoE4 is also associated with greater neuronal inflammation (Grainger et al., 2004; Guo et al., 2004; Kim et al., 2009; Leduc et al., 2011) and less efficient neuronal repair (Mauch et al., 2001; Bu, 2009; Mahley et al., 2009; Leduc et al., 2011), two other conditions that might influence the risk of AD.