Even though the activation of complement factor can also alter the expression of metalloproteases 2/9 as well as their activity along with imbalance in VEGF to PEDF ratio, these results suggest the effect of activated complement which could further induce the proangiogenic environment for neovascularization in AMD (Bandyopadhyay and Rohrer, 2012). Here, VEGFA is linked to age-related macular degeneration.