Another report has documented the genetic network in injured retina reporting increased expression of Ier3 gene with other transcription factors such as Crem, Egr1, Fos, Fosl1, Junb, Btg2, Atf3, and Nr4a1 etc. Together, these genes implicate an angiogenic pathway attributed to CFH independent mechanism, popularly accepted to be responsible for almost half of AMD cases. This evidence concerns the gene CFH and age-related macular degeneration.