While for AD and CTL individuals there was no significant association with APOE e4 status, possibly indicating that cognitively normal individuals seemed to be well preserved irrespectively of their APOE status (Ferencz et al., 2013; Khan et al., 2014), and AD patients would show a high degree of cognitive decline and atrophy independent of their APOE status (Aguilar et al., 2013). The gene discussed is APOE; the disease is Alzheimer disease.