SOD1 and Alzheimer disease: AD is another brain pathology characterized by neurodegeneration that produces a broad spectrum of symptoms that have been linked to copper brain depletion since cupro-proproteins such as ceruloplasmin are decreased (Connor et al., 1993; Bush, 2003) or less active as observed for superoxide dismutase 1 (Omar et al., 1999; Maynard et al., 2005).