For example, blockade of BDNF signaling through its TrkB receptor, or through function-blocking anti-BDNF, disrupted LTM but not STM for a conditioned IA event, whereas infusion of recombinant BDNF into hippocampus rescued IA memory from amnesia induced by glucocorticoid receptor blockade (Chen et al., 2012). The gene discussed is BDNF; the disease is amnesia.