In the brain there are two species of STIM, STIM1, which has been shown recently to link to mGluRs and play a critical role in cerebellar neurons (Hartmann et al., 2014), and STIM2 (Sun et al., 2014) which appears to regulate influx of calcium in forebrain neurons, and be related to Alzheimer’s disease (AD) (below). This evidence concerns the gene STIM1 and Alzheimer disease.