It has been shown that miR-7 and miR-153 target α-synuclein, a protein critically involved in PD pathogenesis (Junn et al., 2009; Doxakis, 2010) and most importantly that miR-7 levels are down-regulated in the midbrain of mice intraperitoneally injected with the PD neurotoxin, MPTP (Junn et al., 2009). This evidence concerns the gene SNCA and Parkinson disease.