LRRK2 and Parkinson disease: Knockout of LRRK2 in the mouse yielded a strong phenotype in the kidney pointing to a role for LRRK2 in autophagy, however, no clear differences in the brain; this suggests that mammalian LRRK2 in vivo models do a better job of modeling cellular function/dysfunction rather than providing a more general model of PD (Tong et al., 2010).