Mutations associated with ALS result in the redistribution of TDP-43 from the nucleus to the cytoplasm (Igaz et al., 2011), although the precise mechanisms by which TDP-43 contributes to ALS pathogenesis remain the subject of intensive study (Janssens and Van Broeckhoven, 2013). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.