Next, we sought to analyze the expression profile of the genes that have been found altered in the chordoma tumors, such as the T gene and COL2A1. Both the zebrafish homolog ntla and col2a1a were found to be significantly up-regulated in fas/fasl-MO-injected-embryos by qPCR analyses (p≤0,05) (Fig. 3 A-B). This evidence concerns the gene COL2A1 and chordoma.