Since AuNP lowered the IC50 value of cisplatin and pruned ovarian cancer cells towards chemosensitization by depleting stem cell pools and inhibiting NF-κB/Akt signaling axis, we wanted to investigate whether a low dose of cisplatin could be used to effectively inhibit ovarian tumor growth in AuNP treated animals. This evidence concerns the gene AKT1 and ovarian neoplasm.