Since AuNP treatment reversed EMT in cancer cells by reducing secretion of TGF-β, bFGF and uPA, proteins involved in EMT, up-regulating E-Cadherin, and down-regulating Snail, N-Cadherin, and Vimentin both in vitro and in vivo [20], we hypothesized that AuNPs can potentially act as a multifunctional molecule to increase sensitivity of cells towards cisplatin. This evidence concerns the gene VIM and cancer.