BECN1 and glioblastoma: As previously demonstrated, an oncolytic adenovirus overexpressing beclin-1, a central protein for autophagy induction and regulation [58], had a significantly enhanced cytotoxicity compared to parental OV lacking beclin-1 in a leukemic cancer model in vitro and in vivo [59], whereas inhibition of autophagy via chloroquine resulted in enhanced oncolytic activity in glioblastoma [60], indicating that cellular prerequisites might play an important role in balancing the consequences of viral autophagy induction.