We derived tumor cells from KPC (KRasG12D: p53R172H), Trp53flox (KRasG12D: p53fl), and ARF−/− (KRasG12D: p53R172H:ARF−/−) mice which have been described previously [21, 29, 61-63]. The gene discussed is CDKN2A; the disease is neoplasm.