IFNG and neoplasm: Setiadi et al. in 2007 observed that changes in histone acetylation and chromatin remodelling underlie induction of the TAP-1 expression by IFNγ in TAP-deficient tumour cells [13] and, moreover, massive IFNγ-induced chromatin remodelling of the entire MHC locus, in which both TAP and LMP genes are located, has been shown by Christova et al. [14].