In brief, as shown in Figure 6, Nrf-2 can specifically bind to the P1 and P2 promoter, and a decreased TAp73 and an increased ΔNp73 expression were detected in tumor tissues which is detected hypermethylation [39], which was opposite to the expression in corresponding NCTs which is found hypomethylation. Here, NFE2L2 is linked to neoplasm.