In conclusion, we have established the foundation for using CHMI with PfSPZ Challenge in Africans to establish the efficacy of new interventions against malaria and to study the mechanisms of protection conferred by hemoglobinopathies, glucose 6 phosphate dehydrogenase deficiencies, and innate and acquired immunity to malaria in settings where malaria is endemic. This evidence concerns the gene G6PD and malaria.