Conversely, SIRT1 overexpression antagonizes oncogene-induced cellular senescence in human diploid fibroblasts (Huang et al., 2008), and inhibition of SIRT1 by sirtinol has been shown to induce senescence-like cell growth arrest in human breast cancer MCF7 and human lung adenocarcinoma H1299 cells (Ota et al., 2006). The gene discussed is SIRT1; the disease is breast carcinoma.