During the disease progression, there were 78 (81.3%) patients had more than three areas of bone destruction, 26 (27.1%) patients complicated with pleural effusion, 32 (33.3%) patients complicated with extramedullaryplasmocytomas, 36 (37.5%) patients complicated with anemia, four (4.2%) patients complicated with hypercalcemia, one patient progressed into plasma cell leukemia and one patient complicated with M protein and skin changes (POEMS) syndrome. The gene discussed is MYOM2; the disease is hypercalcemia disease.