ANPEP and diabetes mellitus: Because Hs-CRP/APN ratio highly correlated with BMI, smoking, diabetic mellitus, usage of statins, and meanwhile baseline Hs-CRP/APN ratio significantly correlated with CIMT progression and the incidence of clinical events, we considered that further study should be focused on lifestyle modification, glucose control and usage of statins so as to find out whether tough control of these risks factors and more intensive therapy with statins could improve the Hs-CRP/APN ratio which finally results in better clinical outcomes.