CDH1 and breast cancer: Furthermore, considering the aberrant expression of E-cadherin is a common event in primary invasive ductal carcinomas that progress to develop distant metastases, we investigated the role of SAMC on regulating E-cadherin and found that SAMC was able to improving E-cadherin expression by western blot assay as shown in Figure 3B. These results indicate that SAMC treatment led to suppression of breast cancer cell migration, and may also be effective agents for the treatment of invasive cancers.