To verify how ISL-1 is regulated by JNK and JAK/STAT signal pathways, we first analyzed the basal expression levels and correlations of p-c-Jun, p-STAT3, along with ISL-1 and the prominent oncogenic protein c-Myc in a series of NHL cell lines and numbers of human NHL tissue specimens. The gene discussed is MAPK8; the disease is non-Hodgkin lymphoma.