In terms of regulatory mechanism of NHL, we demonstrated that ISL-1 expression was regulated by both JNK and JAK/STAT signaling pathways, p-STAT3/p-c-Jun/ISL-1 could form a transcriptional complex and bind directly to the ISL-1 promoter, indicating that ISL-1 might has a positive feedback regulation. The gene discussed is JUN; the disease is non-Hodgkin lymphoma.