Statistical analysis revealed that there was no significant difference in the expression of ISL-1 between normal lymph nodes and HL samples (p = 0.13), whereas, the positive staining of ISL-1 was significantly correlated with NHLs compared with that in normal lymph nodes (p < 0.001) (Figure 1B).Meanwhile, we found a predominant expression of ISL-1 in a variety of NHL cell lines (Figure 1C,D). This evidence concerns the gene ISL1 and Hodgkins lymphoma.