In our study histological apocrine differentiation was found in 60.7% of molecular apocrine carcinomas; additionally, GCDFP-15 within the molecular apocrine subgroup was associated with histological signs of apocrine differentiation, which suggests that ER/PR, AR, and GCDFP-15 expression are helpful markers to confirm apocrine differentiation in morphologically conspicuous cases. This evidence concerns the gene ESR1 and carcinoma.