ESR1 and neoplasm: Using the currently by ASCO/CAP guidelines [19] recommended cutoff for ER/PR evaluation (<1% stained tumor cells = negative, > = 1% stained tumor cells = positive) we obtained similar results: HR positivity rate in the total study group was 79.5%, GCDFP-15 expression still was associated with HR positivity (p = 0.046) and with molecular apocrine tumor type (p < 0.0001), although the rate of molecular apocrine tumors was now decreased to 6.5%.