Chronic immune activation, including elevated proportions of activated CD4+ and CD8+ T-cells and of T-regulatory cells, irreversible loss of gut mucosal integrity and later destruction of lymph nodes, is known to be common among HIV-infected adults [34-36], and may play a key role in the pathophysiology of hypertension among HIV-infected adults on ART in SSA. This evidence concerns the gene CD4 and hypertensive disorder.