Furthermore, ABCE1-siRNA was found to inhibit proliferation and invasion in breast cancer cells, significantly induce breast cancer cell apoptosis (P<0.05) in vitro and increase the protein expression of RNase L. These findings showed that ABCE1 had an important role in proliferation, invasion and apoptosis in MCF-7 human breast cancer cells and that ABCE1 may inhibit intracellular RNase L activity, which inhibits the 2-5A/RNase L pathway, interfering with the biological characteristics of breast cancer cells. The gene discussed is RNASEL; the disease is breast carcinoma.