IFNG and neoplasm: The antitumor activity could be contributed to integrative immunoregulation, such as activation of NK cells, increase in adaptive T-cell responses, elevation in neutralizing antibody specific for NY-ESO-1, induction of ADCC activity against antibody-coated tumor cells, enhancement of Th1-type cytokine secretion (IFN-γ), and accentuation of CTL activity.