Subsequently, these HBS1L-MYB variants have been shown to also modulate HbF levels in healthy subjects of African and East Asian descent and in SCA and β-thalassemia patients and carriers of diverse ethnic origin (Lettre et al., 2008; Gibney et al., 2008; So et al., 2008; Creary et al., 2009; Galanello et al., 2009; Makani et al., 2010; Solovieff et al., 2010; Galarneau et al., 2010; Nuinoon et al., 2010; Farrell et al., 2011; Bae et al., 2012). The gene discussed is MYB; the disease is autosomal dominant cerebellar ataxia.