ACVR1C and colorectal carcinoma: In the network, miR-9 has the largest out-degree and regulates 142 genes, which again highlights its importance in CRC development; while ACVR1C, also known as ALK7, has the largest in-degree of 7 and is down-expressed in the studied patient samples (log2 fold change −0.91), it is a type I receptor for the TGFB family of signaling molecules and has been found inducing apoptosis through activating SMADs and MAPKS in tumor cells [60].