Among them the Src family member YES1 has been reported as a direct miR-145 target that plays oncogenic function in colon cancer [33], FSCN1 and PPP3CA are also directly regulated by this miRNA in esophageal squamous cell carcinoma and urothelial carcinoma [34, 35]. The gene discussed is PPP3CA; the disease is esophageal squamous cell carcinoma.