APP and Alzheimer disease: Specific to AD, the ALP has been documented to regulate APP turnover and Aβ metabolism (Mueller-Steiner et al, 2006; Nixon, 2007; Pickford et al, 2008; Rohn et al, 2011; Yang et al, 2011) as well as Tau protein degradation (Wang et al, 2009, 2010; Kruger et al, 2012; Schaeffer et al, 2012; Caccamo et al, 2013; Ozcelik et al, 2013).