HIF1A and breast cancer: Notably, according to three target prediction programs (TargetScan, PicTar and miRBase), most of the CoCl2-responsive genes affected by miR-18a lack target sites of miR-18a, suggesting that miR-18a regulates CoCl2-responsive genes primarily through indirect mechanisms.To investigate whether miR-18a-mediated HIF1A inhibition can be extended to other basal-like breast cancer cell lines, we examined the impact of ectopic miR-18a expression in MDA-MB-436 cells.