A recent piece of research indicated that 15-deoxy-Delta12,14-prostaglandin J2 (a novel kind of PPARγ ligand) exerts cytotoxic effects on RCC cells via activation of c-Jun N terminal kinase (JNK)/MAPK and Akt pathways, in addition to induction of apoptosis [76]. This evidence concerns the gene PPARG and renal cell carcinoma.