Although no correlation was observed between serum IGFBP-3 levels and RCC [45,50], high expression of IGFBP-3 was found in clear cell RCC tissue, and high grade (Fuhrman grades 3 and 4) clear cell RCC showed higher IGFBP-3 staining intensity than low grade clear cell RCC [51]. The gene discussed is IGFBP3; the disease is renal cell carcinoma.