To further study whether BV could overcome chemoresistance of cancer cells, we co-treated lung cancer cells with a combination of a lower concentration of BV (1 μg/mL) and TWEAK, a ligand of DR3, since DR3 was overexpressed by BV and siRNA of DR3 reversed the cell growth inhibitory effect of BV in both cells. Here, TNFSF12 is linked to lung cancer.