We also found that (E)-2, 4-bis (p-hydroxyphenyl)-2-butenal has an inhibitory effect on the growth of lung cancer cells due to the induction of apoptosis through the up-regulation of DRs (DR3, DR5 and DR6) and equally the inactivation of NF-κB [45]. The gene discussed is TNFRSF21; the disease is lung cancer.