To further study whether BV could overcome chemoresistance of cancer cells, we co-treated lung cancer cells with a combination of a lower concentration of BV (1 μg/mL) and TWEAK, a ligand of DR3, since DR3 was overexpressed by BV and siRNA of DR3 reversed the cell growth inhibitory effect of BV in both cells. Here, TNFSF12 is linked to cancer.