KLK3 and neoplasm: These findings, together with the ability of PSA to process a number of growth regulatory proteins that are important in cancer growth and survival (such as Insulin-like growth factor binding protein, Parathyroid hormone-related protein, latent Transforming growth factor-beta 2 as well as extracellular matrix components, like fibronectin and laminin) [11]-[14], indeed suggest that PSA can facilitate tumor growth and metastasis dissemination [3], [15], [16].