LCN2 and acute kidney injury: The adjusted biomarker level to creatinine was not found to be superior to unadjusted value for NGAL in detecting AKI at 24 hours but was found to be superior for IL-18 NGAL and IL-18 being tubular markers are supposed to rise in the urine only when there is intrinsic tubular AKI and not in pre-renal AKI.