The observation that the top ranked hypermethylated BRCA1-mutation associated CpGs are highly enriched for PCGTs which we and others have previously shown to be an epigenetic hallmark of cancer tissue [12-18] and which are among the earliest, if not the earliest, molecular changes in human carcinogenesis [18] was an exciting finding because it fully supports recent data demonstrating that a BRCA1 defect leads to retargeting of the PRC2 and reduces cell differentiation. The gene discussed is BRCA1; the disease is cancer.