BRCA1 and breast carcinoma: In order to test whether the BRCA1-mutation DNAme signature is able to predict not only incidence but also breast cancer mortality we performed ROC statistics in the UKCTOCS set comparing women who died from breast cancer (n = 10) during the follow-up period with women who did not develop breast cancer (Figure 3E) and found an AUC = 0.67 (0.51 to 0.83; P = 0.02).