We found that, in contrast to the WT construct, neither of the cancer-associated mutant BAF180 constructs was able to fully rescue either the DSB repair defect or the failure to arrest transcription observed in the BAF180-depleted cells (Figures 6B and 6C), raising the possibility that the function of BAF180 in repressing transcription near DSBs contributes to its tumor suppressor activity. Here, PBRM1 is linked to cancer.