MAPT and semantic dementia: This fly tauopathy model uses hTauR406W (hereafter Tau* for short), a mutant Tau found in some FTDP-17 patients (Reed et al., 1997; Saito et al., 2002; van Swieten et al., 1999), and displays increased toxicity over wild-type Tau (Wittmann et al., 2001).