To represent genotypes relevant to melanoma we selected melanoma cell line pairs that harbor the V600E BRAF mutation, the most common mutation present in melanoma (Wellbrock and Hurlstone, 2010), but differ in their expression of MITF, and as a consequence the individual cell lines are either inherently invasive (MITFlow) or poorly invasive (MITFhigh). This evidence concerns the gene MITF and melanoma.