In addition, aberrant elevated expressions of RBPMS2 were specifically observed in digestive myopathy syndrome (CIPO) and gastrointestinal mesenchymal neoplasm (GIST), demonstrating that RBPMS2 expression and function must be tightly regulated to avoid SMC dedifferentiation (9,11). The gene discussed is RBPMS2; the disease is gastrointestinal stromal tumor.