VCAN and interstitial lung disease: In contrast, 6 proteins were more than 2-fold downregulated, such as collagen IV alpha2 (COL4A2), laminin alpha3 (LAMA3) and member B of C-type lectin domain family 3 (CLEC3B).TNC and VCAN gene expression, as well as domain EDA of the FN, were individually analyzed in ILD patients (Figure 2A).