In contrast, 6 proteins were more than 2-fold downregulated, such as collagen IV alpha2 (COL4A2), laminin alpha3 (LAMA3) and member B of C-type lectin domain family 3 (CLEC3B).TNC and VCAN gene expression, as well as domain EDA of the FN, were individually analyzed in ILD patients (Figure 2A). This evidence concerns the gene COL4A2 and interstitial lung disease.