ABCC6-silenced fibroblasts showed even slightly increased or unaltered mRNA levels under LPDS cultivation in comparison to siRNA controls (Figures 3 and 4).Cell cultivation in 10% LPDS increased mRNA expression of all targets in PXE and control fibroblasts, as well as in siRNA treated cells in comparison to 10% FCS (Figures 3 and 4). Here, ABCC6 is linked to Pseudoxanthoma elasticum.