These data were confirmed by further qPCR measurements of important targets in cholesterol biosynthesis (FDPS, GGPS1, FDFT1, LSS, TM7SF2, DHCR7), which revealed overall increased transcript levels in PXE patients, predominately under serum starvation and using LPDS. The gene discussed is TM7SF2; the disease is pseudoxanthoma elasticum (inherited or acquired).