Lactate dehydrogenase B (LDH-B) is upregulated in tumor endothelium, and VEGF signaling increases glycolytic flux by inducing GLUT1 and the glycolytic enzyme 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase-3 (PFKFB3) (Fig 2A) (van Beijnum et al, 2006; Yeh et al, 2008; De Bock et al, 2013b). This evidence concerns the gene PFKFB3 and neoplasm.