MARVELD2 and deafness: Tricellulin, a TJ transmembrane protein, was also identified as a responsible gene for human hereditary deafness DFNB49 (Chishti et al., 2008; Riazuddin et al., 2006) and knockin mice of tricellulin mutant gene, which mimics one of DFNB49-associated mutations, exhibited profound deafness (Nayak et al., 2013).