CXCL8 and cancer: In addition, an increase in IL-8 levels was demonstrated at several diseases associated with osteoclast activation, including rheumatoid and psoriatic arthritis (Cho et al., 2007; Fitzgerald and Chandran, 2012), and several cancers exhibiting high propensity to metastasize to bone, such as breast (Bendre et al., 2005; Bendre et al., 2003), lung (Hsu et al., 2010), renal (Perut et al., 2009) and oral squamous cell carcinoma (Hwang et al., 2012).