It is noteworthy that the risk imparted by the minor A allele was higher than that by the C allele in obese subjects (P = 0.008 for allele analysis and P < 0.001 for genotype analysis), thus prompting the speculation of a possible interaction between IGF2BP2 (rs4402960) and obesity in determining overall T2DM risk. The gene discussed is IGF2BP2; the disease is obesity due to melanocortin 4 receptor deficiency.