Although normally nuclear proteins, in the disease state, TDP-43, FUS, EWSR1 and TAF15 accumulate in cytoplasmic inclusions in the degenerating motor neurons of individuals with ALS (Couthouis et al., 2012; Couthouis et al., 2011; Robberecht and Philips, 2013). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.