TARDBP and amyotrophic lateral sclerosis: In ALS, several different RNA-binding proteins with prion-like domains, including TDP-43, FUS, EWSR1 and TAF15, are implicated in the disease in certain subsets of affected individuals (Couthouis et al., 2012; Couthouis et al., 2011; King et al., 2012; Robberecht and Philips, 2013).