Thus, we tested them against EWSR1, another RNA-binding protein with a prion-like domain that is implicated in ALS and FTD (Couthouis et al., 2012; Couthouis et al., 2011; King et al., 2012; Mackenzie and Neumann, 2012; Robberecht and Philips, 2013). This evidence concerns the gene EWSR1 and frontotemporal dementia.