FUS and amyotrophic lateral sclerosis: Thus, potentiated Hsp104 variants suppress the toxicity of FUSWT, which forms cytoplasmic aggregates in FTD-affected individuals, as well as the toxicity of rare ALS-linked FUS variants that are found in familial forms of ALS (Lagier-Tourenne et al., 2010; Robberecht and Philips, 2013).