Numerous missense mutations in TDP-43, FUS and α-syn have been identified and implicated in ALS and PD, respectively (Pesiridis et al., 2009; Polymeropoulos et al., 1997; Robberecht and Philips, 2013; Zarranz et al., 2004). This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.