PPARG and obesity disorder: Grun et al. (2006) suggested that exposure to environmental obesogens may play a role in the obesity epidemic. That a growing number of environmental PPARγ agonists are being shown to not only enhance adipocyte differentiation but also suppress osteogenesis suggests that environmental toxicants may contribute to loss of bone health. Patisaul et al. (2013) reported that prenatal and postnatal exposure to FM550 resulted in obesity and increased anxiety and early puberty in rats.