The results show a comparable body weight for both wild type and Wnt1-Cre; pMes-stop Shox2 mice at birth, but this differs significantly at P7 and at other time points, indicating that the changes of condyle and glenoid fossa in Wnt1-Cre; pMes-stop Shox2 mice may affect the function of TMJ, resulting in the loss of body weight, and develop a wasting syndrome, clinically defined as TMJ disorders. Here, WNT1 is linked to Cachexia.