EGF and neoplasm: [20] SCC-Ag is a generic name for a homologous class of serine proteinase inhibitors (serpins) for which a number of encoding genes, including SCC-Ag 1 and SCC-Ag 2, have been identified. [21] SCC-Ag promotes tumorigenesis by inhibiting apoptosis or increasing cell migration after stimulation by epidermal growth factor and plays a role in tumor invasion and metastasis.