CRP and neoplasm: In Table 4, multivariate analysis indicated that high SCC-Ag (≥2.0 ng/ml) and CRP (≥5.0 mg/L) levels significantly influenced OS after recurrence (P<0.001, H.R. [95% CI]: 5.406 [2.210–13.222]) after adjusting for the recurrent tumor stage and patient age.