CRP and neoplasm: The patients were divided into four groups according to the presence of high or low SCC-Ag and CRP levels, and a close association was observed between the coexistence of high SCC-Ag (≥2.0 ng/ml) and high CRP (≥5.0 mg/L) and recurrent tumor status (P<0.001), recurrent nodal metastasis (χ2 trend test: P = 0.020), and distant metastasis (P<0.001) (Table 2).